DNA Viruses

By completing this question set, you will apply the herpesvirus latency framework from File 7 to each of the eight human herpesviruses, predicting reactivation syndrome from latency cell type. You will explain why HSV-1 encephalitis involves the temporal lobe specifically, why VZV zoster follows a dermatomal pattern without crossing the midline, and why EBV mononucleosis produces atypical lymphocytes that are CD8+ T cells rather than infected B cells. You will interpret the complete HBV serology table including the window period and vaccinated-only patterns, and explain why HBV can cause HCC without cirrhosis through the HBx protein. You will distinguish CMV disease manifestations by immune status and transplant context, identify the owl-eye inclusion body pathognomically, and distinguish congenital CMV from toxoplasmosis by calcification pattern. You will apply HPV E6 and E7 oncoprotein mechanisms to explain the molecular basis of cervical carcinogenesis, distinguish low-risk from high-risk HPV consequences, and explain why koilocytes represent the histopathologic fingerprint of HPV infection. You will explain Parvovirus B19 erythroid tropism and predict why aplastic crisis occurs in hemolytic anemias but not in normal hosts. You will distinguish the four poxvirus clinical entities by morphology of lesion and immune status.