This file owns SLE as a clinical systemic disease: pathogenesis, ACR/EULAR criteria, the ANA-driven autoantibody panel and its clinical interpretation, multi-organ manifestations as recognition signals (mucocutaneous, musculoskeletal, serositis, hematologic, neuropsychiatric, cardiopulmonary), the systemic disease frame for SLE complications (lupus nephritis, APS, Libman-Sacks endocarditis, pregnancy in SLE, neonatal lupus), drug-induced lupus distinction, and MCTD as the anti-U1 RNP overlap syndrome.
Prerequisites
Approach to Inflammatory Arthritis & Rheumatoid Arthritis (the four-pillar inflammatory arthritis framework: joint pattern + autoantibody + extra-articular feature + acute-phase reactants — directly applied here; anti-CCP vs RF specificity logic; the principle that complement consumption distinguishes SLE from RA)MSK Anatomy, Histology, Embryology & Joint Biology (synovial joint structure — for the Jaccoud's non-erosive arthropathy contrast with RA's erosive disease)HLA class II structure and antigen presentation; HLA-DR2 and HLA-DR3 associations with SLEType III hypersensitivity (immune-complex deposition); tolerance breakdown via molecular mimicry, defective apoptotic clearance, and epitope spreading; complement classical pathwayBasic obstetrics (placental transfer of IgG)Basic cardiology (the cardiac conduction system, valvular vegetation patterns)