Rheumatology · Metabolic Bone Disease with Ca/PO₄/PTH/ALP/Vit D Pattern Table as Diagnostic Discriminator
Metabolic bone disease organized around the Ca/PO₄/PTH/ALP/Vit D pattern table as the master diagnostic discriminator: osteoporosis (postmenopausal, age-related, glucocorticoid-induced, secondary endocrine causes) with DEXA + FRAX + fracture pattern reasoning; osteomalacia and rickets (vitamin D deficiency, hypophosphatemic including X-linked hypophosphatemic rickets and oncogenic osteomalacia, hereditary 1α-hydroxylase deficiency, vitamin D-resistant); Paget's disease of bone (isolated ↑ALP with normal Ca/PO₄, mosaic woven-and-lamellar pattern, complications including high-output cardiac failure, hearing loss, secondary osteosarcoma); renal osteodystrophy as the bone-manifestations side of CKD-MBD (high-turnover osteitis fibrosa cystica from secondary HPT, low-turnover adynamic bone disease, mixed disease, β2-microglobulin amyloid); and the primary/secondary/tertiary hyperparathyroidism lab pattern triplet.