Pulmonology · Thoracic oncology module
By completing this question set, you will be able to identify lung cancer as the #1 cause of cancer death and describe major risk factors (smoking, radon, asbestos synergy). You will classify NSCLC into adenocarcinoma (peripheral, TTF-1+, most common, EGFR/ALK molecular markers), squamous cell (central, keratin pearls, PTHrP hypercalcemia, cavitation), and large cell (peripheral, diagnosis of exclusion). You will describe SCLC (central, oat cells, neuroendocrine, most aggressive, limited vs extensive staging, SIADH/ACTH/LEMS). You will match each paraneoplastic syndrome to its cancer type and distinguish Lambert-Eaton from MG. You will recognize Pancoast tumor (Horner syndrome + brachial plexus invasion) and SVC syndrome. You will evaluate a solitary pulmonary nodule using benign vs malignant criteria, identify hamartoma and bronchial carcinoid, and apply appropriate workup (PET-CT, biopsy). You will describe mesothelioma (asbestos, NOT smoking, calretinin+) and distinguish it from pulmonary adenocarcinoma by IHC.