A 68-year-old woman with ischemic cardiomyopathy and a left ventricular ejection fraction of 20% is admitted after an episode of hypotension at home — her blood pressure on arrival is 78/50 mmHg. She is resuscitated with vasopressors over the next several hours. Labs drawn the following morning show AST 4,200 U/L (normal 10–40), ALT 3,800 U/L (normal 7–56), and LDH 2,800 U/L. Hepatitis serologies are negative, and she has taken no acetaminophen or new medications. A liver biopsy reveals hepatocyte necrosis concentrated around the central veins, with relative preservation of hepatocytes adjacent to the portal triads.
Which of the following best explains the pattern of hepatocellular injury seen on this patient's liver biopsy?